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This change of the LDL is realized mainly by oxidation with the free radicals that appear in large amounts in hypertension, diabetes mellitus, as a consequence of smoking, or in viral and bacterial infections, but LDL may be also modified by glycation (in type II diabetes mellitus), by association with proteoglycans or by incorporation in immune complexes [Ross, 1999]

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Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinsons disease